Individuals metabolize drugs through the same CYP enzyme pathways at different rates so there is no way to know how much CBD can cause a drug interaction or tolerance in a particular person. As CBD inhibits the CYP450 enzyme system, the elimination rate of caffeine will slow down. This can prolong the effects of the caffeine in your body which can be both good and bad. CBD is quickly gaining ground and now people are combining the two as both substances seem to work well together. There is a higher risk for mood swings in people who are suffering from bipolar disorder, which is why patients should not take anxiety-inducing THC.
The interaction between CBD and Cytochrome P450 is most prominent in anti-seizure medications designed for treating epilepsy. CBD is known to inhibit the ability of Cytochrome P450 enzymes to metabolize certain drugs, leading to a much longer processing time. According to the Davis Drug Guide, there are more than 50 enzymes that process and eliminate toxins from the body.
These medications are designed to relieve symptoms of anxiety and depression although they do not work for everyone. Some people are unable to feel relief from antidepressant medications alone. There is insufficient information on how CBD interacts with medication designed to lower blood pressure.
While everyone is different, one of the things that can play a role in whether or not you have a negative experience is the quality of the CBD oil that you use. Using low-quality CBD oil that isn’t transparent about where its CBD is sourced or what other ingredients it contains is dangerous.
Macrolide antibiotics, benzodiazepines, immune modulators, HIV antivirals, calcium channel blockers, HMG CoA reductase inhibitors, anticoagulants and steroids are a few of the types of medications that may be affected by CBD hemp oil for cats. A quick online search or a discussion with your physician can help you understand if the medications you are taking might be metabolized by the P450 enzyme pathway.
There has been no report of negative effects from the interaction between CBD and sedatives but the potential impact of this combination is not fully known. While THC can induce drowsiness and lethargy, the sedative effects of CBD are calming and wake-inducing. Benzodiazepines (ativan, valium), barbiturates (phenobarbital), and narcotics (codeine) are known to produce a calming effect by influencing GABA neurotransmitters in the central nervous system. CBD, THC, and terpenes (myrcene and linalool) can also produce sedative effects through this pathway. The most popular antidepressants are SSRIs, SNRIs, and tricyclic.
One study in 2015 found that the anticonvulsant clobazam (CLB) and CBD both metabolized along the CYP pathway. During the 8-week trial, 13 children with refractory epilepsy took CLB and CBD together. The researchers found elevated blood concentrations of CLB, with 10 of the 13 subjects reporting side effects.